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Sketch of various possible forms of NikR. Rectangles represent metal binding domains (each color represents a different chain, purple and lime represent intertwined chains). Trapezoids represent the DNA binding domains (each has contributions from two chains). Grey circles represent primary nickel binding sites. Only the three with names written in blue were found experimentally in the absence of DNA. In the cis form, NikRs DBDs snugly fit into the major groove of DNA.
