Table 2.
F5M2 and F4: spontaneous pulmonary metastasis
| Cell sublines | Percent spontaneous pulmonary metastasis (%)a | Survival (spontaneous pulmonary metastasis) median (days ± SD)b | Number of spontaneous pulmonary metastasisc |
|---|---|---|---|
| F5M2 (n = 15) | 100 | 71 ± 2d | >200 |
| F4 (n = 15) | 33.3 | Not achieved at day 120 | 12 |
aPercentage of tumor bearing mice developing spontaneous pulmonary metastasis (χ2 test, p < 0.001)
bMetastasis-associated morbidity-free survival in mice with primary tumors
cEvaluation of pulmonary metastasis with injection of India ink 42 days post transplantation. Data represent evaluation of pulmonary metastases in ten mice
dMedian survival of mice transplanted with F5M2 cells is significantly shorter than those transplanted with F4 cells (Student’s t-test, p < 0.001)