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View full-text article in PMC

. 2009 Dec 29;4(12):e8240. doi: 10.1371/journal.pone.0008240

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Paauw et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Along with yersiniabactin, aerobactin, deferoxamine, and deferiprone also reduce ROS production by PMNs. To determine the effect of other iron-binding molecules on ROS production by PMNs, PMNs were pre-incubated with aerobactin, deferoxamine, deferiprone, or yersiniabactin. The pre-treated PMNs were then activated using PMA, and the production of ROS was measured using luminol. Red line: the concentration-dependent decrease in ROS production following yersiniabactin treatment. Gray line: the decrease in ROS production following treatment with aerobactin. Yellow line: the concentration-dependent decrease in ROS production following deferiprone treatment. Green line: the concentration-dependent decrease in ROS production following deferoxamine treatment. The level of ROS produced by stimulated PMNs without additives was set as 100%. All experiments were replicated three times, and each sample was analyzed in duplicate.