Skip to main content
. 2009 Oct 20;158(6):1477–1485. doi: 10.1111/j.1476-5381.2009.00406.x

Figure 1.

Figure 1

Effect of the putative 5-HT2C receptor agonist WAY 161503 on 5-hydroxytryptamine (5-HT) cell firing in the dorsal raphe nucleus of the anaesthetized rat. (A) Spike train (upper trace) and rate-meter recording of the inhibitory effect of WAY 161503 on the firing of a single 5-HT neurone and reversal by the 5-HT2C receptor antagonist SB 242084 administered 2 min after the final dose of WAY 161503. (B) Group data on effect of WAY 161503, followed by SB 242084. Data are mean + standard error of the mean values, n= 6 cells. *P < 0.01, **P < 0.001 versus pre-drug values. #P < 0.05 versus WAY 161503 (1.0 mg·kg−1 i.v.; one-way analysis of variance with least significant difference post hoc test). (C) Recordings of the inhibitory effect of WAY 161503 and reversal by SB 242084 administered 38 min later. Doses of WAY 161503 as indicated by arrows are 0.125, 0.25, 0.5 and 1.0 mg·kg−1 i.v.