Figure 5.
Effect of the 5-hydroxytryptamine (5-HT) releasing agent 3,4-methylenedioxymethamphetamine (MDMA) on 5-HT cell firing. (A) Spike train (upper trace) and rate-meter recording of the inhibitory effect of MDMA on the firing of a single 5-HT neurone. The inhibition was not affected by SB 242084 or ritanserin, but reversed by WAY 100635. Doses in mg·kg−1. (B) Group data of the effect of MDMA. Data are mean + standard error of the mean values, n= 6. *P < 0.05, **P < 0.01, ***P < 0.001 versus pre-drug values. #P < 0.001 compared with MDMA (1.6 mg·kg−1 i.v.; one-way analysis of variance with least significant difference post hoc test).