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. 2009 Oct 8;158(6):1513–1526. doi: 10.1111/j.1476-5381.2009.00425.x

Figure 6.

Figure 6

Antagonism of ATP-stimulated ethidium accumulation in cells expressing the dog P2X7 receptor. HEK293 cells expressing the dog P2X7 receptor were pre-incubated for 40 min with antagonist before measuring ATP-induced ethidium accumulation. Antagonists were pre-incubated with cells for 40 min before measuring the response to 2 mM ATP. The data are the mean ± SEM of 3–4 separate experiments. GSK314181, 5-{[(3R)-3-amino-1-pyrrolidinyl]methyl}-2-chloro-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)benzamide; GW791343, N2-(3,4-difluorophenyl)-N1-[2-methyl-5-(1-piperazinylmethyl)phenyl]glycinamide dihydrochloride; PPADS, pyridoxal phosphate-6-azophenyl-2′,4′-disulphonic acid.