Table 2.

Effect of ATP and 2′- & 3′-O-(4benzoylbenzoyl) ATP (BzATP) at rat, human and dog P2X7 receptors in electrophysiological studies

	BzATP			ATP
	pEC50	Hill slope	Max current (nA)	pEC50	Hill slope	Max current (nA)
Rat	4.4 ± 0.10	1.2 ± 0.3	6.1 ± 1.5	3.1 ± 0.03	2.0 ± 0.3	4.3 ± 0.4
Human	3.4 ± 0.04*	1.8 ± 0.3	3.6 ± 0.6	2.6 ± 0.03*	2.5 ± 0.5	2.7 ± 0.6
Dog	3.3 ± 0.03†	2.1 ± 0.2	3.5 ± 0.8	2.5 ± 0.05†	0.8 ± 0.1	2.5 ± 1.5

The maximal currents for ATP and BzATP were determined at the standard concentration for each orthologue. For ATP this was 3, 10 and 30 mM, respectively, for studies on rat, human and dog P2X7 receptors. For BzATP the standard concentration was 0.3, 1 and 3 mM, respectively, for studies on rat, human and dog P2X7 receptors.

^*Significantly different (P < 0.05) from value at rat P2X7 receptor but not significantly different to value at dog P2X7 receptor.

^†Significantly different (P < 0.05) from value at rat P2X7 receptor. Data are mean ± SEM, n= 3–11 experiments.