Figure 5.
Effect of isoprenaline alone (Iso, 30 nM) or in the additional presence of cumulatively applied carbachol in isolated right atria on rate of contraction (frequency) plotted in beats per minute (bpm). Ctr indicates control values (prior to drug addition). Littermate wild-type mice (+/+, open circles) are compared with Gi2α knockout (Gi2α−/−, A) or Goα knockout mice (Goα−/−, B). Numbers in brackets indicate number of mice studied. * denotes first significant difference of additionally applied carbachol versus Iso (alone) value. No differences were detectable between wild type and knockout mice.