Figure 6.
Effects of carbachol alone or in the presence of isoprenaline (30 nM) in isolated left atria on force of contraction (FOC) plotted in mN (A) or in percentage of control values (Ctr, prior to drug addition, B). Solvent-treated Gi2α knockout (Gi2α−/−) mice are compared with PTX-treated mice (PTX). Numbers in brackets indicate number of mice studied.* denotes first significant difference versus pre-drug value (A) or versus Iso alone (B). + denotes significant differences versus solvent pretreatment.