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Time-dependent effects of isoprenaline alone (Iso, 10 µM) and in the additional presence of carbachol (Carb) on current through the L-type Ca2+-channels (ICa, nA) in isolated, patch-clamped ventricular cardiomyocytes from littermate wild-type mice (Go+/+, A) compared with Goα knockout mice (Goα−/−, B). Representative tracings from five cardiomyocytes from three different Goα+/+ and Goα−/− hearts are shown.
