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Effects of EP3 receptor modulators. (A) GR63799X, EP3 receptor agonist. (B) CM9, EP3 receptor antagonist. (C) DG041, EP3 receptor antagonist. (D) Representative dose–response to GR63799X on cells expressing human EP3 receptors. Data are expressed as a percentage of the maximum PGE2 response. (E) Representative dose–response curves to CM9 and DG041 demonstrating a complete inhibition of the PGE2-evoked response at the rat EP3 receptor.
