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EP3 receptor antagonists CM9 and DG041 increased bladder capacity. (A) Representative recording of the effect of 10 mg·kg−1 CM9 on cystometric urodynamics. CM9 and DG041 increased void volume (B) and micturition interval (C), compared with vehicle treatment. Data are expressed as a percentage of control for each group. Vehicle (n= 18), CM9 (10 mg·kg−1, n= 8) and DG041 (30 mg·kg−1, n= 8). (*P < 0.05, **P < 0.01, vs. vehicle, unpaired t-test).
