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Potencies of EP3 receptor antagonists in the fluorescence imaging plate reader assay
| Human EP3 | Rat EP3 | ||
|---|---|---|---|
| CM9 | pIC50 | 7.03 ± 0.04 (n= 101) | 6.58 ± 0.04 (n= 73) |
| fpKi | 7.77 ± 0.04 | 7.12 ± 0.04 | |
| DG041 | pIC50 | 7.66 ± 0.04 (n= 101) | 7.04 ± 0.03(n= 70) |
| fpKi | 8.41 ± 0.04 | 7.57 ± 0.03 | |
pIC50 values were measured in response to an EC80 challenge of the EP3 receptor agonist PGE2.
