Table 1.
SB265610 (nmol·L−1) | Bmax (fmol·mg−1) | Kd (nmol·L−1) | n |
---|---|---|---|
0 | 254.3 ± 14.7 | 0.132 ± 0.02 | 5 |
1 | 289.9 ± 14.8 | 0.141 ± 0.01 | 3 |
3 | 170.2 ± 22.2** | 0.146 ± 0.01 | 4 |
10 | 96.1 ± 6.1** | 0.118 ± 0.03 | 3 |
30 | 31.9 ± 6.8** | 0.111 ± 0.02 | 3 |
Data are mean ± s.e.mean for the indicated number of experiments.
P < 0.01 (one-way anova followed by Dunnett's multiple comparison test) indicates Bmax value significantly different from Bmax in the absence of SB265610.
CHO, chinese hamster ovary; CXCR, C-X-C chemokine receptor; IL-8, interleukin-8.