Table 4.

K_A, K_B and τ and β values determined by fitting the data in Figure 7 to the operational allosteric ternary complex model (Equation 6)

Parameter	[35S]-GTPγS binding
	IL-8	GROα
pKA	−6.13 ± 0.07	−6.40 ± 0.08
pKB	−8.72 ± 0.01	−8.63 ± 0.04
τ	110.5 ± 22.2	161.6 ± 29.5
β	0.0018 ± 0.0018	0.0029 ± 0.0003

For this analysis, α was fixed to 1.0. Data are mean ± s.e.mean from at least three separate experiments.

GRO, growth related oncogene; IL-8, interleukin-8.