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EP1 receptor antagonists. The natural ligand PGE2 is shown in the box. The dibenzoxazepine residue in SC-51322 is shown in blue. Aryl-sulphonamido residues in antagonists with prostanoid and non-prostanoid structures are shown in cerise; ONO-NT-012 contains a styryl-sulphonamido moiety. The 1,2-biaryl-cyclopentene pharmacophores in GW-848687 and MF-266-1 are shown in red. Ring A in GW-848687 is part of a picolinic acid (pyridine-2-carboxylic acid) residue.
