Figure 3.

Intrinsic activities of long-acting β-agonists as inhibitors of histamine release and eicosanoid generation. In this figure, intrinsic activities were calculated by considering the E_max for inhibition by a long-acting β-agonist divided by inhibition by a maximally effective concentration (1 µmol·L⁻¹) of the full agonist isoprenaline on IgE-dependent histamine release, PGD₂ and cys-LT generation. Each point represents the intrinsic activity of (A) indacaterol (n= 7), (B) formoterol (n= 11) and (C) salmeterol (n= 11) in an individual experiment. Note that not all mast cell preparations generated cys-LTs following activation with anti-IgE. Solid horizontal bars represent the mean intrinsic activities.