Table 2.
pD2 and Emax values for long-acting β-agonists for the inhibition of histamine, PGD2 and cys-LT generation from mast cells
|
Indacaterol |
Formoterol |
Salmeterol |
||||
|---|---|---|---|---|---|---|
| pD2 | Emax (%) | pD2 | Emax (%) | pD2 | Emax (%) | |
| Histamine | 9.6 ± 0.3 | 33 ± 6 | 9.0 ± 0.3 | 37 ± 6 | 9.6 ± 0.5 | 8 ± 3 |
| PGD2 | 9.8 ± 0.3 | 62 ± 4 | 9.8 ± 0.2 | 66 ± 5 | 9.4 ± 0.1 | 58 ± 5 |
| cys-LT | 10.2 ± 0.3 | 66 ± 7 | 9.1 ± 0.3 | 77 ± 7 | 10.2 ± 0.2 | 81 ± 4 |
Values were calculated from the data used to generate Figure 2 and further relevant details can be found in the legend to that figure. In the experiments described in Figure 3, a single concentration (10−6 mol·L−1) of isoprenaline was also studied for inhibitory effects on IgE-dependent mediator release. Isoprenaline (10−6 mol·L−1) inhibited histamine, PGD2 and cys-LT generation by 37 ± 4%, 67 ± 6% and 74 ± 5% respectively (n= 12). Values in the table are means ± SEM.