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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Am J Med Genet A. 2009 Dec;149A(12):2745–2752. doi: 10.1002/ajmg.a.33130

Table V.

Gene-gene interactions for Hox and IGFBP3 SNPsa,b

A. Discovery
Gene1 SNP1 Gene2 SNP2 p-value Pop
HOXD rs2113563 (SNP6) IGFBP3 rs3793345 (SNP26) 0.008 NHW
rs2113563 (SNP6) rs2471551 (SNP27) 0.007 NHW
rs2592394 (SNP7) rs3793345 (SNP26) 0.003 NHW
rs2592394 (SNP7) rs2471551 (SNP27) 0.001 NHW
rs741610 (SNP9) rs13223993 (SNP32) 0.002 H
rs711812 (SNP10) rs13223993 (SNP32) 0.003 H
HOXA rs3801776 (SNP16) rs13223993 (SNP32) 0.0001 NHW
rs6968828 (SNP19) rs2854747 (SNP25) 0.003 NHW
rs6968828 (SNP19) rs3110697 (SNP28) 0.001 NHW
B. Validation
Gene1 SNP1 Gene2 SNP2 p-value
HOXD rs1542180 (SNP4) IGFBP3 rs2854747 (SNP25) 0.002
rs1542180 (SNP4) rs3110697 (SNP28) 0.0003
rs1542180 (SNP4) rs2453839 (SNP30) 0.002
rs2592394 (SNP7) rs3110697 (SNP28) <0.0001
rs2592394 (SNP7) rs2453839 (SNP30) 0.004
rs2592394 (SNP7) rs2854747 (SNP25) 0.0006
rs847146 (SNP8) rs2854747 (SNP25) 0.004
rs847146 (SNP8) rs3110697 (SNP28) 0.001
HOXA rs2462907 (SNP12) rs2471551 (SNP27) 0.007
a

Only p<0.01 shown, p<0.001 in bold,

NHW=nonHispanic white H=Hispanic,

b

p-values uncorrected for multiple testing