Table 3.

Interim analysis of rhDNase data at several looks starting from April 9, 1992. (i) Using log-rank statistic adjusted for FEV₁. (ii) Using log-rank statistic unadjusted for FEV₁.

Analysis date	Average study time	${\widehat{\sigma }}_w^2$	Current D̂1g	Current D̂1a	Current D̂2	Projected D̂1g	Projected D̂1a	Projected D̂2	Sample size	p-value
(i)
May 9	62	0.160	0.190	0.192	0.056	0.512	0.519	0.410	586	0.076
May 29	81	0.367	0.262	0.265	0.100	0.535	0.541	0.418	639	0.053
June 18	101	0.383	0.323	0.329	0.143	0.531	0.555	0.389	641	0.019
July 18	129	0.183	0.428	0.433	0.236	0.549	0.562	0.390	546	0.029
August 17	153	0.279	0.515	0.519	0.335	0.558	0.560	0.393	576	0.057
August 27	159	0.278	0.534	0.540	0.362	0.555	0.559	0.392	571	0.028
September 6	164	0.299	0.549	0.553	0.380	0.554	0.560	0.389	578	0.034
September 24	165	0.314	0.554	0.560	0.389	0.554	0.557	0.391	584	0.023
(ii)
May 9	62	0.452	0.185	0.187	0.045	0.499	0.505	0.326	692	0.084
May 29	81	0.703	0.257	0.260	0.080	0.525	0.532	0.334	734	0.060
June 18	101	0.693	0.320	0.325	0.117	0.525	0.534	0.317	721	0.023
July 18	129	0.437	0.425	0.430	0.194	0.545	0.551	0.319	614	0.031
August 17	153	0.554	0.513	0.517	0.275	0.555	0.559	0.322	632	0.059
August 27	159	0.552	0.532	0.537	0.298	0.552	0.558	0.321	636	0.030
September 6	164	0.571	0.547	0.552	0.314	0.552	0.557	0.320	640	0.036
September 24	165	0.595	0.551	0.557	0.321	0.551	0.557	0.321	649	0.025