Figure 1.

Predicting the expression category for a CRM based on its temporal transcription factor binding profile. Peak heights for five factors at five developmental time points (15 conditions total) are sufficient to predict the expression category of a mesodermal enhancer with a >70% success rate. Shown is a schematic representation of the temporal binding profile of a single CRM and a support vector machine (SVM) used for the predictions, as well as the categories mesoderm, somatic muscle, and visceral muscle with example expression patterns. Photomicrographs reproduced from Zinzen et al (2009).