Fig. 7.

Feeding cue is essential for rhythmic transcription of a subset of transcripts and is integrated into the circadian clock through Per1 and Per2. (A and C) Mice were fasted for 24 h and re-fed at CT4 or left under fasted condition. mRNA levels of Per1 and Per2 in the livers of fasted (black) or re-fed (red) mice were determined by RT-qPCR at 2-h resolution. (B and D) mRNA levels of Per1 and Per2 in the liver of cry1^−/−;cry2^−/− mice under tRF conditions were determined by RT-qPCR at 4-h resolution.