Fig. 1.

Primate OR7D4 orthologs and hypothetical OR7D4 ancestors exhibit functional divergence in response to androstenone and androstadienone. Dose-response curves of (A) all intact primate OR7D4 orthologs and (B) reconstructed hypothetical OR7D4 for the catarrhine ancestor (α), Great Ape ancestor (β), hominine ancestor (γ), human, bonobo, and chimpanzee ancestor (δ), and chimpanzee and bonobo ancestor (ε) to androstenone (Left) and androstadienone (Right) are assessed in a luciferase assay system. y axis denotes normalized response ± SEM. (n = 4). The EC₅₀ value of each dose–response curve is shown.