Table 2.
HMGA2 Genotype Associations with Anthropometric and Bone Mineral Density Measures in Afro-Caribbean Men.
| Trait | Genotype Mean (SE) |
p-valueb | ||
|---|---|---|---|---|
| C/C (n=759) | C/T (n=733) | T/T (n=180) | ||
| Height (cm) | 174.85 (0.23) | 175.20 (0.24) | 175.07 (0.47) | 0.4105a |
| Weight (kg) | 84.22 (0.53) | 84.71 (0.55) | 84.14 (1.09) | 0.5804r |
| Radius BMD (mg/cm3) | ||||
| Trabecular | 208 (2) | 206 (2) | 200 (3) | 0.0220r |
| Cortical | 1213 (1) | 1210 (1) | 1208 (2) | 0.0180a |
| Tibia BMD (mg/cm3) | ||||
| Trabecular | 230 (1) | 227 (1) | 222 (3) | 0.0071a |
| Cortical | 1178 (1) | 1174 (1) | 1173 (2) | 0.0054a |
| Proximal Femur BMD (g/cm2) | ||||
| Total Hip | 1.15 (0.005) | 1.15 (0.005) | 1.13 (0.010) | 0.0852r |
| Femoral Neck | 1.00 (0.005) | 0.99 (0.005) | 0.97 (0.010) | 0.0166r |
b
p-value of the best fit model are shown, age adjusted;
a
additive model;
r
recessive model. The P values highlighted in bold face achieve Bonferroni adjusted statistical significance accounting for the six BMD traits (P<0.008).