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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Exp Gerontol. 2009 May 4;44(8):493–502. doi: 10.1016/j.exger.2009.04.004

Fig. 6.

Fig. 6

Deletion of the AKT kinase gene sck2+ extends lifespan under normal conditions while deletion of the gene for the paralogous kinase sck1+ does not. A-C) Chronological lifespans of sck1Δ and sck2Δ single and double mutants grown in normal SD medium (3% glucose), with CFU/ml plotted on a log scale. The KRP14 sck1Δ strain shows a lifespan the same as KRP19 wildtype (wt) cells (p = 0.46) while the KRP20 sck2Δ and KRP21 sck1Δsck2Δ strains show extended lifespans (p < 0.001 for sck2Δ and sck1Δ sck2Δ). The sck2Δ and sck1Δ sck2Δ lifespans are statistically indistinguishable from each other (p > 0.05). D-F) The data from panels A-C plotted as normalized log10(CFU/ml) to show the fraction of viable cells over the course of the lifespan. The median lifespans determined from these data are: KRP19 wildtype 8.3 days; KRP14 sck1Δ 8.7 days; KRP20 sck2Δ 10.6 days; KRP21 sck1Δ sck2Δ 10.5 days.