Table 1.
Baseline characteristics among the Caucasian, African-American, and Hispanic participants from the candidate gene substudy
| Characteristic | Caucasian n=712 | African- American n=712 | Hispanic n=705 | p-value* |
|---|---|---|---|---|
| Age, years | 61.5±10.4 | 61.5±9.9 | 61.2±10.1 | 0.74 |
| Gender, n (%) | ||||
| Male | 332 (46.6) | 321 (45.1) | 324 (46.0) | 0.84 |
| Female | 380 (53.4) | 391 (54.9) | 381 (54.0) | |
| Field Center, n (%) | ||||
| Wake Forest | 183 (25.7) | 179 (25.1) | 1 (0.14) | <0.001 |
| Columbia | 59 (8.3) | 153 (21.5) | 244 (34.6) | |
| Johns Hopkins | 115 (16.2) | 215 (30.2) | 0 (0) | |
| Minnesota | 170 (23.9) | 0 (0) | 202 (28.7) | |
| Northwestern | 133 (18.7) | 104 (14.6) | 0 (0) | |
| UC-Los Angeles | 52 (7.3) | 61 (8.6) | 258 (36.6) | |
| Education ≥ college, n (%) | 552 (77.5) | 492 (69.1) | 239 (33.9) | <0.001 |
| Income ≥ $40,000/year, n (%) | 463 (65.1) | 328 (46.1) | 172 (24.4) | <0.001 |
| Current smoker, n (%) | 112 (15.7) | 135 (19.0) | 106 (15.0) | 0.09 |
| Hypertension, n (%) | 277 (38.9) | 398 (55.9) | 295 (41.8) | <0.001 |
| Diabetes, n (%) | 32 (4.5) | 97 (13.6) | 95 (13.5) | <0.001 |
| Chronic kidney disease, n (%) | 89 (12.5) | 47 (6.6) | 56 (7.9) | <0.001 |
| Systolic BP, mmHg | 124.2±21.1 | 129.6±20.9 | 126.0±21.8 | <0.001 |
| Diastolic BP, mmHg | 70.6±9.9 | 73.9±9.8 | 71.3±10.3 | <0.001 |
| Fasting glucose, mg/dL | 97.2±19.7 | 107.0±33.2 | 110.4±40.5 | <0.001 |
| HDL cholesterol, mg/dL | 52.6±16.0 | 52.9±15.4 | 47.5±12.6 | <0.001 |
| LDL cholesterol, mg/dL | 117.3±31.0 | 116.3±33.0 | 119.9±32.4 | 0.10 |
| Triglycerides, mg/dL† | 113.0 (87.0) | 91.0 (57.0) | 137.0 (88.5) | <0.001 |
| Body mass index, kg/m2 | 27.7±5.3 | 30.1±5.8 | 29.5±5.1 | <0.001 |
| Waist circumference, cm | 97.8±15.1 | 101.0±14.5 | 100.4±12.8 | <0.001 |
| C-reactive protein, mg/L† | 1.79 (3.63) | 2.59 (4.54) | 2.43 (3.69) | <0.001 |
| Common carotid IMT, mm | 0.87±0.21 | 0.91±0.19 | 0.86±0.18 | <0.001 |
| Internal carotid IMT, mm | 1.09±0.59 | 1.10±0.61 | 1.02±0.56 | 0.02 |
| Coronary artery calcium > 0, n(%) | 393 (55.2) | 301 (42.3) | 317 (45.0) | <0.001 |
| Coronary artery calcium score (>0)† | 107.7 (335.3) | 77.7 (310.4) | 73.6 (238.4) | 0.34 |
| Lipid-lowering med use, n(%) | 112 (15.7) | 122 (17.1) | 103 (14.6) | 0.41 |
| Anti-hypertension med use, n (%) | 230 (32.3) | 351 (49.3) | 231 (32.8) | <0.001 |
*
p-value by ANOVA, chi-square or Kruskal-Wallis as appropriate
†
Median (Interquartile range)