Table 2.
Patient no. | IGHD II | Age (yr) | Height at Dx | Age at Dx (months) | Bone age (months) | Ht SDS before Rx | GH Peak (ng/ml) | IGF-I (ng/ml) | IGFBP-3 | TSH (μ U/ml) | T4 (μ g/dl) |
---|---|---|---|---|---|---|---|---|---|---|---|
III-1 | No | 11 | ND | ND | ND | 0.46 | ND | ND | ND | ND | ND |
III-2 | Yes | 8 | 88.6 | 37 | 28 | −2.02 | 2.2 | <5 | 0.4 | 2.49 | 8.9 |
III-3 | Yes | 5 | 70.5 | 14.5 | 15 | −2.46 | ND | <5 | 0.5 | NA | NA |
III-4 | Yes | 2 | 72 | 16 | NA | −2.41 | 3.3 | <10 | 0.8 | 1.59 | 8.8 |
III-5 | Yes | 1 | 71.2 | 1.04 | ND | −1.93 | Pending | 33 at 12m | NA | NA | NA |
III-6a | Yes | 6 | 75.7 | 27 | NA | −4.13 | 1.12/1.14 | 28.8 | 1.2 | 1.18 | 1.33 |
III-7 | Yes | 2 | 80 | 18 | NA | −1.87 | ND | 31 | ND | 1.66 | 6.2 |
Dx, Diagnosis; Rx, treatment; IGFBP, IGF binding protein; ND, not determined; NA, not available.
MRI of III-6 showed pituitary hypoplasia.