Figure 8.

Immunoblot analysis of cell lysates from skin fibroblasts of seven patients with APS. Shown is a representative immunoblot of cell lysates obtained from the fibroblasts of patients with APS probed with amino terminal-specific antilamin A/C antibody, N-18, showing lamin C and mature lamin A. None of the APS patients showed accumulation of any abnormal species of lamins A or C. Included were also cell lysates from a patient with HGPS (AG06917), demonstrating accumulation of progerin, a patient with MAD due to ZMPSTE24 deficiency (MAD 3300.3) showing accumulation of prelamin A (40), and a normal healthy subject (control).