Table 1.
GHRP-2 effect on serum cytokine levels
| PBS | GHRP-2 | P value | |
|---|---|---|---|
| GH (ng/ml)a | 2.0 ± 0.6 | 1.8 ± 0.5 | 0.93d |
| IGF-I (ng/ml)a | 180 ± 11 | 240 ± 20 | 0.02 |
| IGFBP-2 (ng/ml) | 46 ± 7 | 27 ± 6 | 0.049 |
| IGFBP-3 (ng/ml)a | 291 ± 8 | 333 ± 15 | 0.022 |
| IGFBP-5 (ng/ml)b | 18 ± 1 | 15 ± 2 | 0.22 |
| IFN-γ (ng/ml)c | 5.3 ± 1.2 | 1.8 ± 0.6 | 0.027 |
| IL-6 (pg/ml)c | 125 ± 46 | 357 ± 143 | 0.37d |
| IL-10 (pg/ml) | 2600 ± 700 | 2900 ± 1500 | 0.24d |
| Leptin (ng/ml) | 2.2 ± 0.9 | 3.0 ± 1.0 | 0.67d |
| MCP-1 (pg/ml) | 53 ± 7 | 63 ± 6 | 0.49d |
| RANTES (pg/ml) | 610 ± 64 | 600 ± 87 | 0.91 |
| SDF-1α (pg/ml)b | 790 ± 670e | 640 ± 430e | 0.96d |
| TNF-α (pg/ml)c | 0 ± 0 | 35 ± 35f | 0.30 |
Fasting levels of GH, IGF-I, IGFBP-2, IGFBP-3, IGFBP-5, IFN-γ, IL-6, IL-10, leptin, MCP-1, Regulated upon Activation Normal T-cell Expressed and Secreted (RANTES), stromal cell-derived factor-1α (SDF-1α), and TNF-α.
a–c Except as follows, n = 9 for all groups:
a
n = 15 per group;
b
n = 8 in the PBS group;
c
n = 8 in the GHRP-2 group.
d
P value obtained by Mann Whitney U test.
e
Only two mice per group had detectable levels of SDF-1α.
f
Only one mouse had detectable levels of TNF-α.