Table 1.
Characteristics of selected SNPs, and associations between the CHD incidence and SNPs
| HR estimates (95% CI) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Closest gene | Gene name | SNP [reference] | Chr | Physical position | Risk allele | MAF | Heterozygous genotype | Homozygous genotype | p-Value |
| GJA4 | gap junction protein, alpha 4 | rs618675 [4] | 1 | 34922761 | C | 0.19 | 1.32 (1.01, 1.72) | 1.73 (1.01, 2.97) | 0.0451 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | rs2114580 [4] | 1 | 55167236 | A | 0.24 | 1.22 (0.94, 1.59) | 1.49 (0.88, 2.54) | 0.1376 |
| PSRC1 | proline/serine-rich coiled-coil 1 | rs599839 [5] | 1 | 109623689 | A | 0.22 | 1.05 (0.79, 1.41) | 1.11 (0.62, 1.98) | 0.7262 |
| MIA3 | melanoma inhibitory activity family, member 3 | rs17465637 [5] | 1 | 220890152 | C | 0.29 | 1.07 (0.82, 1.39) | 1.14 (0.67, 1.93) | 0.6282 |
| FMN2 | formin 2 | rs17672135 [6] | 1 | 238512219 | C | 0.11 | 1.20 (0.83, 1.73) | 1.44 (0.69, 2.99) | 0.3286 |
| OR13G1 | olfactory receptor, family 13, subfamily G, member 1 | rs1151640 [7] | 1 | 245902573 | C | 0.43 | 0.98 (0.77, 1.25) | 0.96 (0.59, 1.56) | 0.8628 |
| rs2943634 [5] | 2 | 226776324 | C | 0.35 | 1.08 (0.84, 1.39) | 1.16 (0.71, 1.92) | 0.5508 | ||
| rs10516882 [4] | 4 | 92127599 | C | 0.17 | 1.19 (0.85, 1.67) | 1.41 (0.72, 2.78) | 0.3170 | ||
| THBS4 | thrombospondin 4 | rs264986 [4] | 5 | 79206180 | T | 0.27 | 1.01 (0.77, 1.32) | 1.01 (0.59, 1.74) | 0.9656 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase 1-like | rs6922269 [5] | 6 | 151294678 | A | 0.27 | 1.13 (0.87, 1.48) | 1.29 (0.76, 2.18) | 0.3506 |
| PHACTR1 | phosphatase and actin regulator 1 | rs1512411 [4] | 6 | 13439076 | C | 0.34 | 1.01 (0.78, 1.31) | 1.03 (0.61, 1.71) | 0.9235 |
| WNT2 | wingless-type MMTV integration site family member 2 | rs39312 [4] | 7 | 116742021 | A | 0.35 | 1.06 (0.83, 1.35) | 1.12 (0.68, 1.83) | 0.6554 |
| CDKN2A/2B | cyclin-dependent kinase inhibitor 2A/2B | rs1333049 [6] | 9 | 22115503 | C | 0.48 | 1.28 (1.01, 1.63) | 1.64 (1.02, 2.66) | 0.0433 |
| rs501120 [5] | 10 | 44073873 | C | 0.14 | 0.99 (0.71, 1.39) | 0.99 (0.50, 1.94) | 0.9681 | ||
| KIAA0528 | KIAA0528 | rs10505879 [4] | 12 | 22539123 | G | 0.22 | 1.13 (0.86, 1.50) | 1.28 (0.74, 2.24) | 0.3753 |
| TAS2R50 | taste receptor, type 2, member 50 | rs1376251 [7] | 12 | 11030119 | C | 0.33 | 1.31 (1.00, 1.71) | 1.71 (1.01, 2.92) | 0.0476 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | rs7984952 [4] | 13 | 30129806 | T | 0.43 | 1.24 (0.97, 1.58) | 1.54 (0.95, 2.51) | 0.0817 |
| rs7995384 [4] | 13 | 30177259 | T | 0.29 | 1.20 (0.92, 1.57) | 1.44 (0.84, 2.48) | 0.1830 | ||
| rs117395 [4] | 13 | 30365911 | T | 0.13 | 1.09 (0.75, 1.59) | 1.19 (0.56, 2.52) | 0.6459 | ||
| SMAD3 | SMAD family member 3 | rs17228212 [5] | 15 | 65245693 | C | 0.29 | 1.04 (0.80, 1.35) | 1.08 (0.64, 1.81) | 0.7781 |
| rs2549513 [4] | 16 | 78108228 | C | 0.13 | 1.03 (0.73, 1.47) | 1.06 (0.53, 2.15) | 0.8617 | ||
| CDH13 | cadherin 13, H-cadherin | rs8055236 [6] | 16 | 81769899 | T | 0.19 | 1.26 (0.95, 1.67) | 1.59 (0.91, 2.78) | 0.1045 |
| SEZ6L | seizure related 6 homolog | rs688034 [6] | 22 | 25019635 | C | 0.33 | 1.10 (0.84, 1.43) | 1.20 (0.71, 2.04) | 0.4971 |
| Risk Scorea | 1.32 (1.13, 1.54) | 0.0004 | |||||||
aThe HR estimated the hazard of having incident CHD for one unit increase in the risk score