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Strongest signals of rare variant association with RA (p < 10-4) outside of the MHC, adjusting for the effects of HLA-DRB1a
| Rare variants | |||||
|---|---|---|---|---|---|
| Gene | Chromosome | Number | Mean MAF (%) | Odds ratio (95% CI) | p-value |
| TRIM58 | 1 | 3 | 1.1 | 0.04 (0.01-0.18) | 3.7 × 10-5 |
| HINT1 | 5 | 4 | 3.0 | 0.25 (0.13-0.48) | 4.6 × 10-5 |
aEach gene-based test has been adjusted for sex, five axes of genetic variation to account for population structure, and the number of shared epitope alleles to allow for the effects of HLA-DRB1.
