Table 3.
Weighted GRS results and GRS associations with lipid/lipoprotein levelsa
| Mean (LDL-C & HDL-C)/median (TG) in GRS by quartile | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| GRS | Min | Max | Mean | S.D. | 1 | 2 | 3 | 4 | p-Value |
| GRS-LDL | -34.8 | 15 | -2.69 | 6.8 | |||||
| LDL-C | 107.2 | 115.8 | 118.1 | 122.2 | 2.1 × 10-24 | ||||
| HDL-C | 53.9 | 53.5 | 52.3 | 53.0 | 0.07 | ||||
| TG | 81.0 | 83.0 | 83.0 | 81.0 | 0.04 | ||||
| GRS-HDL | -10.2 | 17 | -1.28 | 3.5 | |||||
| LDL-C | 116.1 | 116.3 | 117.2 | 115.1 | 0.6 | ||||
| HDL-C | 50.5 | 51.7 | 54.3 | 56.2 | 5.9 × 10-22 | ||||
| TG | 83.0 | 87.0 | 84.0 | 76.0 | 3.4 × 10-6 | ||||
| GRS-TG | -26.0 | 31 | -2.10 | 8 | |||||
| LDL-C | 115.1 | 116.6 | 117.4 | 115.5 | 0.43 | ||||
| HDL-C | 54.9 | 54.1 | 51.5 | 52.5 | 7.7 × 10-9 | ||||
| TG | 72.0 | 79.0 | 86.0 | 94.0 | 5.4 × 10-25 | ||||
aResults of association testing using a linear mixed model with family membership included in the model as a random-effects variable. Phenotype values are in mg/dL