Table 1.

Analysis variables, corrections and total heritabilities

LDL-c			Heritabilities
Scheme	Method of adjustment	Correction	Visit 1	Visit 3
1	No correction, ignore medication status	None	43.8%	25.2%
2	No correction, assign medicated values as missing	None	44.3%	33.5%
3	No correction, treat medication (Y/N) as covariate	(Covariate)	43.6%	30.1%
4	Use clinical trials data to correct LDLa	X + 48.1 mg/dl	46.6%	47.9%
5	Use GAW16 simulation protocol to correct LDLb	X/(1 - 0.3)	46.6%	50.1%
6	Over-correct LDL (1)	X + 75 mg/dl	46.6%	50.0%
7	Over-correct LDL (2)	X + 100 mg/dl	45.7%	48.5%

^aSee Wu et al. [6] for details.

^bOriginal values were reduced by 30% [X = Y - 0.3(Y)].