Table 1.

Gene-gene interaction for BMI in FHS data^a

	LNPT analysis of independent individuals in Offspring Cohortb (n = 824) for the trait Longitudinal BMI		Survival analysis of independent individuals in Original and Offspring Cohorts (n = 858) for the trait Event Overweight (BMI ≥ 25)
Modelled factors	Sex and two gene factors		Sex, cohort, and two gene factors
Age adjustment	No	Yes	Age is event time
Time-varying covariates	Nob	Nob	No	Yesh
SNP pair
rs854560 and rs6602024c-e
analyzing exams (T = 1, 4)d	0.022g	0.040g	0.003	0.007
analyzing exams (T = 1,3,4)d	0.092g	n.s.	0.003	0.007
rs854560 and rs1121980	0.034f	0.003f	0.030	0.053
rs854560 and rs9930506	0.048f	0.004f	0.005	0.008
rs6971091c and rs6602024c, e	n.s.	n.s.	n.s.	n.s.
rs6971091c and rs1121980	n.s.	n.s.	n.s.	n.s.
rs6971091c and rs9930506	n.s.	n.s.	n.s.	n.s.
rs6602024c, e and rs1121980	0.053g	0.049g	0.020	0.028
rs6602024c, e and rs9930506	n.s.	n.s.	0.077	n.s.

^ap-Values ≤ 0.1 are given, otherwise marked as not significant (n.s.). Bold font indicates p-values ≤ 0.05.

^bIndividuals with no cholesterol treatment and baseline age 25-46 yr, Exams T = 1,3,4.

^cCarriers of the rare allele for the SNP were pooled for LNPT analysis.

^dSNP pair has a small two-locus genotype strata. LNPT analysis was performed for two sets of exams. Survival analysis used all available event times.

^eMinor allele homozygotes for this SNP were omitted for survival analysis.

^fInteraction of SNP1-SNP2 with number of exam (averaged for sex).

^gInteraction of SNP1-SNP2 with sex and exam number.

^hInclusion of time-varying covariates smoking status and cholesterol treatment.