Table 1.
Summary of single-SNP tests of association: SNPs demonstrating strong evidence of association (p < 1 × 10-5) of association with RA in the combined sex analysis
| SNP | Chromosome | Location (Mb) | MAF | Combined sexes test | Allelic OR (95% CI) |
Sex-differentiated test p-value | Sex interaction test p-value | ||
|---|---|---|---|---|---|---|---|---|---|
| p-value | Allelic OR (95% CI)a |
Females | Males | ||||||
| rs6737562 | 2 | 180.05 | 0.065 | 7.11 × 10-6 | 2.30 (1.60-3.30) | 2.44 (1.61-3.69) | 1.77 (0.82-3.82) | 2.72 × 10-5 | 4.56 × 10-1 |
| rs17533090 | 6 | 32.70 | 0.189 | 1.58 × 10-12 | 2.38 (1.87-3.02) | 2.36 (1.78-3.12) | 2.42 (1.51-3.88) | 3.85 × 10-12 | 7.76 × 10-1 |
| rs2900180 | 9 | 120.79 | 0.340 | 3.23 × 10-8 | 1.68 (1.40-2.02) | 1.87 (1.51-2.33) | 1.25 (0.87-1.77) | 2.22 × 10-8 | 4.86 × 10-2 |
| rs4924 | 16 | 54.95 | 0.462 | 7.36 × 10-7 | 1.56 (1.31-1.86) | 1.47 (1.20-1.80) | 1.84 (1.30-2.61) | 2.00 × 10-6 | 2.80 × 10-1 |
| rs323413 | 17 | 69.24 | 0.410 | 6.53 × 10-6 | 1.49 (1.25-1.77) | 1.59 (1.30-1.94) | 1.25 (0.89-1.76) | 1.42 × 10-5 | 1.98 × 10-1 |
| rs9949777 | 18 | 2.10 | 0.306 | 7.57 × 10-6 | 1.52 (1.27-1.83) | 1.62 (1.31-2.01) | 1.31 (0.91-1.90) | 1.94 × 10-5 | 2.61 × 10-1 |
| rs1182531 | 20 | 57.83 | 0.190 | 2.76 × 10-6 | 1.76 (1.39-2.22) | 1.76 (1.33-2.33) | 1.78 (1.15-2.74) | 1.23 × 10-5 | 8.71 × 10-1 |
aAssumes no heterogeneity of allelic odds ratios between males and females