Table 2.

Drugs used to manage neurophatic pain and their mode of action.

Type	Mode of action	Drug	Side effect
Anticonvulsants	Inhibits opening neuronal voltage –dependent channels (calcium channels, sodium channel ) andGABA receptor.	Carbamazepine Gabapentin Pregabalin Topiramate	Hepatotoxicity, drowsiness, fatigue, ataxia, vertigo, gastrointestinal discomfort headache, blurred vision.
Antidepressants	Inhibits the re-uptake of the neurotransmitters norepinephrine and serotonin by neurons.	Amitriptyline Duloxetine Venlafaxine	Mouth dryness, intense sedation, fatigue, diminished libido, weight loss, nausea, insomnia, headache.
Local anaesthetics	Act mainly by inhibiting sodium influx through sodium-specific ion channels in the neuronal cell membrane.	Lidocaine Mexiletine	Dizzine, arrhythmia.
Analgesics	Act through specific receptors, particularly μ receptors distributed throughout the central and peripheral nervous system blocking them.	Tramadol Dextropropoxyphene Buprenorphine Morphine Oxycodone Fentanyl Methadone	Nausea, vomiting, sweating, dizzines, mouth dryness, sedation, vertigo.