Table 1.
Comparison of demographic variables between CNS malignancy survivors, non-CNS malignancy survivors and siblings
| Characteristics 1,2 | CNS Survivors (n=802) | Non-CNS Survivors (n=5937) | Siblings (n=382) | P(CNS vs. non-CNS) | P (CNS vs. sibs) | P(non-CNS vs. sibs) |
|---|---|---|---|---|---|---|
| Sex | 0.04 | 0.14 | 0.78 | |||
| Male | 419 (52.2%) | 2876 (48.4%) | 182 (47.6%) | |||
| Female | 383 (47.8%) | 3061 (51.6%) | 200 (52.4%) | |||
| Age at time of study | ||||||
| Mean (SD) | 31.5 (7.1) | 32.2 (7.6) | 34.1 (8.4) | 0.01 | 0.002 | <.001 |
| Range | 17.4-51.8 | 17.0-54.1 | 17.8-58.4 | |||
| Median | 31.2 | 31.9 | 33.7 | |||
| Ethnicity | 0.36 | 0.99 | 0.65 | |||
| White | 745 (93.2%) | 5397 (91.2%) | 336 (93.9%) | |||
| Black | 17 (2.1%) | 147 (2.5%) | 8 (2.2%) | |||
| Hispanic/Latino | 20 (2.5%) | 222 (3.8%) | 9 (2.5%) | |||
| Other | 17 (2.1%) | 152 (2.6%) | 5 (1.4%) | |||
| Education | <.001 | 0.003 | 0.37 | |||
| <12 years | 43 (5.4%) | 219 (3.7%) | 9 (2.4%) | |||
| High School Grad. | 455 (56.8%) | 2886 (48.6%) | 181 (47.5%) | |||
| College Grad. | 303 (37.8%) | 2831 (47.7%) | 191 (50.1%) | |||
| Employment | <.001 | <.001 | 0.13 | |||
| Full time | 353 (44.0%) | 3931 (66.2%) | 267 (69.9%) | |||
| Other | 449 (56.0%) | 2006 (33.8%) | 115 (30.1%) | |||
| Household income | <.001 | <.001 | <.001 | |||
| <$19,999 | 163 (21.2%) | 663 (11.4%) | 26 (6.9%) | |||
| $20,000-39,999 | 199 (25.9%) | 1335 (22.9%) | 62 (16.5%) | |||
| $40,000-59,999 | 165 (21.5%) | 1232 (21.1%) | 82 (21.8%) | |||
| Over 60,000 | 241 (31.4%) | 2604 (44.6%) | 206 (54.8%) | |||
| Ever married | <.001 | <.001 | <.001 | |||
| Yes | 277 (34.8%) | 3489 (59.3%) | 271 (71.7%) | |||
| No | 518 (65.2%) | 2391 (40.7%) | 107 (28.3%) | |||
| Age at Diagnosis | <.001 | |||||
| 0-2 | 136 (17.0%) | 1355 (22.8%) | ||||
| 3-5 | 165 (20.6%) | 1325 (22.3%) | ||||
| 6-10 | 232 (28.9%) | 1101 (18.5%) | ||||
| 11-15 | 201 (25.1%) | 1302 (21.9%) | ||||
| 16-20 | 68 (8.5%) | 854 (14.4%) | ||||
| Treatment | <.001 | |||||
| Surgery only | 225 (30.1%) | 280 (5.0%) | ||||
| Chemotherapy only | 0 (0.0%) | 499 (9.0%) | ||||
| Radiation only | 13 (1.7%) | 11 (0.2%) | ||||
| Chemo. + Radiation | 3 (0.4%) | 850 (15.3%) | ||||
| Chemo. + Surgery | 12 (1.6%) | 1164 (20.9%) | ||||
| Radiation + Surgery | 344 (46.1%) | 441 (7.9%) | ||||
| Chemo. +Rad + Surgery | 150 (20.1%) | 2322 (41.7%) | ||||
| Cranial Radiation3 | <.001 | |||||
| None | 268 (37.1 %) | 3910 (71.5%) | ||||
| Whole brain | 218 (30.2%) | 1436 (26.3%) | ||||
| Partial brain | 236 (32.7%) | 124 (2.2%) | ||||
| Cranial Radiation Dose | <.001 | |||||
| None | 268 (37.1%) | 3910 (71.5%) | ||||
| 0.1-19 Gy | 2 (0.3%) | 674 (12.3%) | ||||
| 20-39 Gy | 7 (1.0%) | 762 (13.9%) | ||||
| 40-59 Gy | 423 (58.6%) | 112 (2.0%) | ||||
| >=60 Gy | 22 (3.0%) | 12 (0.2%) | ||||
| Tumor Type | ||||||
| Astrocytoma | 495(61.7%) | |||||
| Medulloblastoma, PNET | 172(21.5%) | |||||
| Other CNS | 135(16.8%) |
Note: Percentages are based on the total with available data for each variable.
1
For categorical characteristics, bootstrap of the families was used to account for the family effect when the p-values were obtained.
2
For continuous characteristics GEE was used to account for the family effect when the p-values were obtained.
3
Does not include patients for whom radiation status was unknown.