Table 1.

Historical review of high-dose radiation nonhuman primate studies detailed in text.

Study Type	Year	Author(s)	TBI Dose	Non-Human Primate Studied	Study Details
Without hematopoietic rescue	1961	Crouch et al.	650 cGy	Macaca mulatta	6 of 6 monkeys died after TBI of 650 cGy
	1965	Van Putten	624 cGy	Macaca mulatta	Highest survivable dose was 624 cGy
	1978	Broerse et al.	525 cGy	Macaca mulatta	LD50 for irradiated monkeys was 525 cGy
With hematopoietic rescue	1965	Van Putten	770 cGy	Macaca mulatta	Effects of cell freezing/thawing on engraftment
	1969	Van Bekkum et al.	760 cGy	Macaca mulatta	Engraftment of allogeneic bone marrow cells
	1978	Broerse et al.	860 cGy	Macaca mulatta	Engraftment of autologous cells
	1987	Monroy et al.	900 cGy	Macaca mulatta	Effects of GM-CSF after autologous transplant
	1988	Berenson et al.	920 cGy	Papio cynocephalus	Engraftment of autologus cells
	1992	Donahue et al.	1000 cGy	Macaca mulatta	Retroviral gene transfer
	1998	Wagemaker et al.	800 cGy	Macaca mulatta	Effects of thrombopoietin after transplant
	2002	Ageyama et al.	1000–1100 cGy	Macaca fascicularis	Engraftment of autologous cells
	2002	Kluge et al.	1000 cGy	Macaca mulatta	Effects of serum versus serum-free conditions
	2004	Bielefeldt-Ohmann et al.	1020 cGy	Macaca nemestrina	Radiation sensitivity of macaques versus baboons
	2007	Jung et al.	1020 cGy	Papio cynocephalus	Intravenous versus intramarrow injection of cells