Table 2.
Summary of sex, age, TBI dose, weights, follow-up time, and outcome for each macaque studied.
| Animal Number |
Sex | Age | TBI Dose |
Nucleated Cell Dose |
Time to ANC > 500/ul |
Weight at Date of TBI |
Weight at End of Study (Percent Weight Loss) |
Follow- Up Time |
Outcome | Bone Marrow Pathology Findings |
|---|---|---|---|---|---|---|---|---|---|---|
| (yr) | (cGy) | (cells/kg) | (days) | (kg) | (kg) | (days) | ||||
| 05105 | Female | 6.3 | 800 | 5.70×106 | 24 | 5.4 | 4.8 (11.1%) | 29 | Autologous Recovery | |
| 05094 | Female | 7.2 | 1020 | 2.13×107 | 20 | 5.6 | 5.0 (10.7%) | 48 | Autologous Recovery | |
| A02175 | Female | 8.0 | 1200 | 1.60×107 | did not recover | 5.8 | 4.6 (20.7%) | 29 | Euthanized | Aplastic, no evidence of hematopoiesis |
| 05082 | Female | 8.4 | 1320 | 2.98×107 | did not recover | 5.6 | 5.6 (0%) | 19 | Euthanized | Aplastic, no evidence of hematopoiesis |
Abbreviations: TBI = total body irradiation, ANC = absolute neutrophil count.