Table 2.

Most significant GO categories that are correlated with miR-29 expression in primary AML samples

	Count	P	Benjamini
GO categories enriched in genes that were negatively correlated with miR-29a and -29b expression
Annotation Cluster 1 (enrichment score 5.09)
Regulation of biologic process	163	<.001	0.009
Biologic regulation	175	<.001	0.005
Regulation of cellular process	152	<.001	0.005
Annotation Cluster 2 (enrichment score 4.76)
Cell death	44	<.001	0.005
Death	44	<.001	0.005
Apoptosis	42	<.001	0.005
Programmed cell death	42	<.001	0.006
Cell development	53	<.001	0.066
GO categories enriched in genes that were negatively correlated only with miR-29b expression
Annotation Cluster 1 (enrichment score 5.27)
Posttranslational protein modification	69	<.001	0.013
Protein modification process	77	<.001	0.014
Biopolymer modification	78	<.001	0.005
Annotation Cluster 2 (enrichment score 3.25)
Protein metabolic process	124	<.001	0.092
GO categories enriched in genes that were negatively correlated only with miR-29a expression
Annotation Cluster 1 (enrichment score 4.93)
Defense response	25	<.001	0.001
Immune response	27	<.001	0.140
Immune system process	31	<.001	0.120
Response to stimulus	52	0.016	0.980
Annotation Cluster 2 (enrichment score 4.93)
Defense response	25	<.001	0.001
Inflammatory response	15	<.001	0.045
Response to wounding	16	<.001	0.230
Response to external stimulus	19	.001	0.550
Response to stress	21	.051	1
GO categories enriched in genes that were positively correlated only with miR-29b expression
Annotation Cluster 1 (enrichment score 13.5)
Intracellular organelle	379	<.001	<0.001
Organelle	379	<.001	<0.001
Intracellular membrane-bound organelle	339	<.001	<0.001
Membrane-bound organelle	339	<.001	<0.001
Annotation Cluster 2 (enrichment score 11.9)
Regulation of cellular process	223	<.001	<0.001
Regulation of biologic process	231	<.001	<0.001
Biologic regulation	244	<.001	<0.001
Annotation Cluster 3 (enrichment score 9.11)
Primary metabolic process	349	<.001	<0.001
Macromolecule metabolic process	311	<.001	<0.001
Cellular metabolic process	339	<.001	<0.001
Metabolic process	364	<.001	<0.001
Annotation Cluster 4 (enrichment score 6.9)
RNA metabolic process	157	<.001	<0.001
Regulation of metabolic process	152	<.001	<0.001
Regulation of cellular metabolic process	145	<.001	<0.001
Regulation of nucleic acid metabolic process	136	<.001	<0.001
Gene expression	175	<.001	<0.001
Transcription	137	<.001	<0.001
Regulation of gene expression	138	<.001	<0.001
Regulation of transcription, DNA-dependent	124	<.001	<0.001
Regulation of transcription	130	<.001	<0.001
Transcription, DNA-dependent	125	<.001	<0.001
RNA biosynthetic process	125	<.001	<0.001
Annotation Cluster 5 (enrichment score 6.34)
Zinc ion binding	124	<.001	<0.001
Transition metal ion binding	139	<.001	0.003
Annotation Cluster 6 (enrichment score 4.99)
Chromatin modification	23	<.001	<0.001
Establishment and/or maintenance of chromatin architecture	27	<.001	0.004
Chromosome organization and biogenesis	31	<.001	0.004
DNA packaging	27	<.001	0.005