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. 2009 Oct 16;23(12):2000–2012. doi: 10.1210/me.2009-0161

Table 2.

Increased pituitary E2F1 and PTTG1 expression in paired Rb+/− and WT mice

Genotype Age (months)
2
3
6
7
10
Rb+/− WT Rb+/− WT Rb+/− WT Rb+/− WT Rb+/− WT Rb+/− WT Rb+/− WT Rb+/− WT
Gender M M F F M M F F F F F F M M M M
Pituitary tumor No No No No Yes Yes No Yes
Pituitary E2F1 expression (%)a 12 6 10 5 8 4 6 1 16 10 15 8 23 14 10 7
Pituitary PTTG1 expression (%)a 9 3 6 0.1 2 0.7 3 1 18 0.2 6 3 14 7 6 0.1

E2F1 and PTTG1 overexpression were observed in eight of 11 Rb+/− mice as assessed by confocal immunofluorescence. In three Rb+/− and WT mice, E2F1 was unchanged and PTTG1 was undetectable (data not shown). E2F1 expression was 12.8 ± 1.4 in Rb+/− vs. 8.8 ± 1.5 in WT (n = 11; P < 0.01); PTTG1 expression was 5.8 ± 1.8 in Rb+/− vs. 1.4 ± 0.7 in WT (n = 11; P < 0.05). F, Female; M, male. 

a

Percentage of immunopositive pituitary cells.