Figure 2. Incidence and latency of reproductive tract tumors in female mice with conditional inactivation of LoxP flanked alleles of Brca1 and/or p53.

A) Fraction of tumor free mice after intrabursal injection of Adenovirus-Cre recombinase. B) Genotyping analysis of DNA isolated from Brca1 ^Δ5-13;p53 ^Δ2-10 and p53^Δ2-10 ovarian tumors. Both the Lox P flanked and excised Brca1 and p53 alleles were amplified from Brca1 ^Δ5-13;p53 ^Δ2-10 tumors (cases 307, 350, 352 355, 397, 399, 411 and 412) and the Lox P flanked and excised p53 allele was amplified from the single p53^Δ2-10 ovarian tumor (case 627). In each panel the left lane contains a DNA ladder and the sizes of the amplified products (nt) are indicated at the right.