. 2009 Dec 31;4(12):e8404. doi: 10.1371/journal.pone.0008404

Table 1. Summary of tumor incidence following intrabursal injection of Ad5-CMV-Cre recombinase.

Genotype	Total number of mice evaluated	Mice with any type of tumor (%)	Tumors with Cre-mediated conditional inactivation (%)^*
*Brca1^LoxP/LoxP*
Bilateral Ad-Cre	40	9 (23)	0
Unilateral Ad-Cre	5	0	0
PBS	6	1 (17)	0
*p53^LoxP/LoxP*
Bilateral Ad-Cre	41	2 (5)	2 (5)
Unilateral Ad-Cre	6	1 (17)	0
PBS	6	0	0
*Brca1^LoxP/LoxP;p53^LoxP/LoxP*
Bilateral Ad-Cre	35	20 (57)	19 (54)
Unilateral Ad-Cre	6	4 (66)	4 (66)
PBS	6	0	0
*Brca1^LoxP/LoxP;p53^515C/WT*
Bilateral Ad-Cre	44	7 (16)	0
Unilateral Ad-Cre	6	2 (33)	0
PBS	6	0	0
*Brca1^LoxP/LoxP;p53^515C/LoxP*
Bilateral Ad-Cre	15^#	3 (20)	2 (13)
Unilateral Ad-Cre	3^#	0	0
PBS	2^#	0	0

Confirmed by PCR amplification of excised product.

Accrual terminated based on results from prior groups.