Figure 10. In virtuo investigation of the functions of TGF-β1 during epidermal wound healing.

TGF-β1 was assumed to be responsible for 60% of cell migration and inhibit 60% of cell hyperproliferation. Its migration function and proliferation inhibition function at subcellular level were blocked respectively in two in-virtuo experiments and the virtual epidermal wound was then simulated 400 interactions. (A) Migration distance and (B) percentage of the wound area that covered by epidermal cells were used to evaluated the influences of the block of two functions on epidermal wound healing.