Figure 1. LCM mice susceptible to S. Typhimurium induced colitis.

Groups (n = 5) of CON, streptomycin-treated mice (20 mg 24 h before infection) and LCM mice were infected with 5×10⁷ cfu S. Typhimurium wild type by gavage and sacrificed at day 3 postinfection. S. Typhimurium levels in the mLN (A), spleen (B) and cecal content (C). (D) Cecal pathology scored in HE-stained tissue sections (see M&M). (E) HE-stained sections of cecal tissue from indicated mice. Enlarged section (white box) is shown in the lower panel. Scale bar: 100 µm.