Table I.
The frequency of reciprocal translocations and other aberration types following EO exposure
| Exposure (weeks) | Concentration (p.p.m.) | Animals (n) | Chromosomal aberrations |
Metaphases scored (n) | Reciprocal translocations (%) (mean ± SE) | Total aberrations (%) (mean ± SE) | |||
| RT | TT | INS | DIC | ||||||
| 6 | 0 | 6 | 0 | 0 | 0 | 0 | 3243 | 0.000 ± 0.000 | 0.000 ± 0.000 |
| 25 | 7 | 1 | 0 | 0 | 0 | 5214 | 0.019 ± 0.019 | 0.019 ± 0.019 | |
| 50 | 7 | 1 | 0 | 1 | 0 | 4619 | 0.021 ± 0.020 | 0.043 ± 0.021 | |
| 100 | 5 | 1 | 0 | 0 | 0 | 3529 | 0.028 ± 0.024 | 0.028 ± 0.028 | |
| 200 | 4 | 1 | 0 | 0 | 0 | 2701 | 0.037 ± 0.037 | 0.037 ± 0.042 | |
| 12 | 0 | 4 | 0 | 0 | 0 | 0 | 2976 | 0.000 ± 0.000 | 0.000 ± 0.000 |
| 25 | 5 | 0 | 2 | 0 | 0 | 3285 | 0.000 ± 0.000 | 0.061 ± 0.016 | |
| 50 | 5 | 1 | 1 | 1 | 0 | 3130 | 0.032 ± 0.036 | 0.070 ± 0.024 | |
| 100 | 4 | 2 | 0 | 2 | 2 | 2508 | 0.080 ± 0.034* | 0.239 ± 0.040* | |
| 200 | 4 | 5 | 0 | 2 | 2 | 2795 | 0.179 ± 0.084* | 0.322 ± 0.068* | |
| 24 | 0 | 4 | 1 | 0 | 0 | 0 | 3134 | 0.032 ± 0.027 | 0.032 ± 0.027 |
| 25 | 7 | 2 | 1 | 1 | 2 | 4770 | 0.042 ± 0.019 | 0.126 ± 0.039 | |
| 50 | 7 | 2 | 3 | 2 | 3 | 4117 | 0.049 ± 0.051 | 0.243 ± 0.119* | |
| 100 | 6 | 5 | 3 | 2 | 4 | 4120 | 0.121 ± 0.042* | 0.340 ± 0.053* | |
| 200 | 5 | 11 | 2 | 4 | 13 | 3581 | 0.307 ± 0.120* | 0.838 ± 0.133* | |
| 48 | 0 | 7 | 0 | 0 | 0 | 0 | 4066 | 0.000 ± 0.000 | 0.000 ± 0.000 |
| 25 | 8 | 1 | 1 | 3 | 3 | 4672 | 0.021 ± 0.019 | 0.171 ± 0.053*# | |
| 50 | 7 | 11 | 5 | 5 | 8 | 5300 | 0.204 ± 0.065* | 0.547 ± 0.138*# | |
| 100 | 7 | 14 | 6 | 0 | 8 | 3883 | 0.361 ± 0.073* | 0.721 ± 0.105*# | |
| 200 | 6 | 19 | 5 | 7 | 16 | 4854 | 0.391 ± 0.096* | 0.968 ± 0.183*# | |
RT, reciprocal translocations; TT, terminal translocations; INS, insertions; DIC, dicentrics.
*P < 0.05 (Fisher's exact test), #P < 0.05 (Cochran–Armitage test).