Table II.
Mutation spectrum for base substitutions in cells expressing the CDG or TDG glycosylases
| Transitions |
Transversions |
|||||||
| Total | AT>GC | GC>AT | Total | AT>TA | AT>CG | GC>TA | GC>CG | |
| LB20a CDGa | 68 | 2 (0.7%) | 66 (24%) | 212 | 4 (1.3%) | 9 (3%) | 53 (19%) | 146 (52%) |
| PAY030a CDG | 15 | 0 | 15 (18.5%) | 66 | 2 (2.5%) | 1 (1%) | 11 (14%) | 52 (64%) |
| LB20a TDGa | 8 | 6 (2%) | 2 (1%) | 244 | 37 (15%) | 185 (73%) | 18 (7%) | 4 (2%) |
| PAY030a TDG | 5 | 1 (1%) | 4 (5%) | 77 | 6 (7%) | 68 (83%) | 3 (4%) | 0 |
PAY030a is a rad30Δ derivative of LB20a. The percentages given for each type of base substitution were calculated from the number of that mutation relative to the total number of base substitutions isolated for that strain. The numbers in italics indicate the total transitions or transversions scored for that strain.
a
Combined data from this study and a previous report (38).