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. Author manuscript; available in PMC: 2010 Nov 4.
Published in final edited form as: J Am Chem Soc. 2009 Nov 4;131(43):15717–15728. doi: 10.1021/ja905065j

Table 7.

Scope of 1,1-disubstituted alkenyl isocyanates.

graphic file with name nihms152020t50.jpg
entry R yield (%)c ee (%) 10d
1 n-Bu, 2e 71 90
2 i-Bu, 2f 75 94
3 Bn, 2g 80 92
4 (CH2)2i-Pr, 2h 83 91
5 (CH2)2Ph, 2i 80 90
6 i-Pr, 2j 50 89
7 Cy, 2k 19 86
8 CH2OCH2Ph, 2l 77 92
9 (CH2)4OTBS, 2m 74 88
10 (CH2)4Cl, 2n 63 90
11 (CH2)2CH=CH2, 2o 75 91
a

See Table 4.

b,d

See Table 1.

c

Isolated yield.