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. 1998 Sep 1;95(18):10722–10727. doi: 10.1073/pnas.95.18.10722

Figure 2.

Figure 2

Pedigree of APC I1307K-carrying individual 1–14. Symbols: solid, individuals affected with gastrointestinal cancers; half-solid, other cancers (not smoking related); quarter-solid, smoking-related cancers; central dot, colorectal adenoma(s); N, no tumors found at colonoscopy. Generations are given on the left in roman numerals. Beneath the symbols are given individual numbers, by generations. Below the individual numbers are given the known tumor type(s) (carcinomas unless otherwise specified) or other cause of death affecting that individual and the age at diagnosis, when known (including any colonoscopy results; nil, no tumors found). Shown below the diagnoses, in parentheses, is the age at death. The proband (individual IV.5; patient 1–14) is indicated with an arrow and is a heterozygous carrier of APC I1307K. Individuals IV.4 and IV.5 have had one surveillance colonoscopy, while IV.2 has had three, commencing at age 48 years; other individuals in generation IV whose phenotypes are unknown have been omitted for clarity. II.7 and II.8 were first cousins through I.2.