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. Author manuscript; available in PMC: 2009 Dec 20.
Published in final edited form as: Lab Invest. 2009 Mar 30;89(6):614–623. doi: 10.1038/labinvest.2009.23

Figure 3. Loss of Stromal Cav-1 Expression Predicts Poor Clinical Outcome in Human Breast Cancer Patients.

Figure 3

Mechanistically, loss of stromal Cav-1 expression in the tumor micro-environment leads to RB-inactivation, increased myofibroblast proliferation, and the secretion of angiogenic growth factors. This, in turn, greatly facilitates tumor recurrence and metastasis, leading to poor clinical outcome.